A team of researchers at IIT Delhi led by Prof Lalan Kumar, Department of Electrical Engineering, IIT Delhi, has come up with a non-invasive EEG based Brain Source Localization (BSL) framework for epilepsy focal detection that is time-efficient and patient-friendly.
Given the EEG data with seizure, the array processing algorithms can point to the coordinates within minutes. In particular, the researchers have proposed novel head harmonics-based algorithms for seizure localisation.
Epilepsy is the fourth most common neurological disorder in the world and affects millions worldwide. It involves brief episodes of involuntary body (partial/entire) movement called seizures and may accompanied by loss of consciousness and control of bowel or bladder function, primarily due to erroneous excessive electrical discharges.
Quite a lot of epilepsies can be controlled by medicines; however, when medicines fail to control seizures, it is labelled as drug-resistant epilepsy.
Drug resistant epilepsies, are most likely to originate from structural abnormalities of brain and hence brain surgery offers a complete cure for these patients, provided the exact origin and extent of abnormality is identified by a neurosurgeon.
The most complex and tedious task in surgical evaluation is to determine the origin of electrical abnormality in epilepsy and correlate it with structural abnormality of the brain.
These structural abnormalities are too subtle to be identified on MRI alone and need to always be interpreted along with electroencephalogram (EEG) evaluation.
Other modalities utilised by neurosurgeons are positron emission tomography (PET) scan, and Magnetoencephalography (MEG). PET scan involves intake of radioactive substance. The MEG facility is very limited in India.
Craniotomy and robot-assisted surgery are invasive where clinicians drill holes into skull to place electrodes on brain. It takes 2-8 hours for Epileptogenic Zone Detection and uncomfortable for patients.
Dr. Amita Giri, a Prime Minister’s Research Fellows (PMRF) in the Department of Electrical Engineering at IIT Delhi, has developed the novel epileptic region detection method as a major part of her PhD work.
The other members of the research team include Professor Tapan K Gandhi, Electrical Engineering Dept., IIT Delhi and Dr. Nilesh Kurwale, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India.
Their study titled ‘Anatomical Harmonics Basis-Based Brain Source Localization With Application To Epilepsy’ was published in Nature’s Scientific Reports.
“We have proposed utilization of spherical harmonics and head harmonics basis functions for seizure localization. To the best our knowledge, this is the first attempt in non-invasive and time-efficient seizure localisation,” Professor Lalan Kumar, Department of Electrical Engineering, IIT Delhi, said.
The researchers have validated the proposed source localisation algorithms on clinical EEG data for epileptogenic zone localisation. The proposed framework offers an effective solution to clinicians in automated and time-efficient seizure localisation.
“It is a breakthrough considering the comfort of patients,” Prof Kumar added.
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